Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of
inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately …

Introduction The unique mucosal immune system allows the generation of robust protective
immune responses at the front line of pathogen encounters. The needle-free delivery route …

Regardless of the eventual site of disease, the point of entry for Mycobacterium tuberculosis
(M. tb) is via the respiratory tract and tuberculosis (TB) remains primarily a disease of the …

The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has resulted in much
human suffering and societal disruption. The ChAdOx1 nCoV-19 vaccine against COVID-19 …

Several studies have demonstrated great potential implications for the gut–lung axis in lung
disease etiology and treatment. The gut environment can be influenced by diet, metabolites …

Vaccines are essential tools to prevent infection and control transmission of infectious
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …

Innate immunity forms a protective line of defense in the early stages of pulmonary infection.
The primary cellular players of the innate immunity against respiratory infections are alveolar …

Alveolar macrophages (AMs) play a critical role during Mycobacterium tuberculosis (Mtb)
infection as the first cells in the lung to encounter bacteria. We previously showed that AMs …

Tuberculosis (TB) remains the leading cause of bacterial disease-related death and is
among the top 10 overall causes of death worldwide. The complex nature of this infectious …

Mucosal tissues are frequent targets of both primary and metastatic cancers. This has
highlighted the significance of both innate and adaptive anti-cancer immunity at mucosal …