[HTML][HTML] DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
[HTML][HTML] The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis
L Liu, J Li, Y Ke, X Zeng, J Gao, X Ba… - Cellular and Molecular Life …, 2022 - Springer
Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases,
particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …
particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …
Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae
M Jaskólska, DW Adams, M Blokesch - Nature, 2022 - nature.com
Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …
A nuclease that mediates cell death induced by DNA damage and poly (ADP-ribose) polymerase-1
Y Wang, R An, GK Umanah, H Park, K Nambiar… - Science, 2016 - science.org
INTRODUCTION Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
Metagenomic discovery of CRISPR-associated transposons
CRISPR-associated Tn7 transposons (CASTs) co-opt cas genes for RNA-guided
transposition. CASTs are exceedingly rare in genomic databases; recent surveys have …
transposition. CASTs are exceedingly rare in genomic databases; recent surveys have …
Type I restriction enzymes and their relatives
WAM Loenen, DTF Dryden, EA Raleigh… - Nucleic acids …, 2014 - academic.oup.com
Type I restriction enzymes (REases) are large pentameric proteins with separate restriction
(R), methylation (M) and DNA sequence-recognition (S) subunits. They were the first …
(R), methylation (M) and DNA sequence-recognition (S) subunits. They were the first …
Type II restriction endonucleases—a historical perspective and more
A Pingoud, GG Wilson, W Wende - Nucleic acids research, 2014 - academic.oup.com
This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease
Known disease mechanisms in mitochondrial DNA (mtDNA) maintenance disorders alter
either the mitochondrial replication machinery (POLG, POLG2 and C10orf2),, or the …
either the mitochondrial replication machinery (POLG, POLG2 and C10orf2),, or the …
Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors
Y Xiao, H Chen, H Wang, M Zhang… - Proceedings of the …, 2021 - National Acad Sciences
Wolbachia bacteria, inherited through the female germ line, infect a large fraction of
arthropod species. Many Wolbachia strains manipulate host reproduction, most commonly …
arthropod species. Many Wolbachia strains manipulate host reproduction, most commonly …
Mitochondrial mechanisms of neuronal cell death: potential therapeutics
Mitochondria lie at the crossroads of neuronal survival and cell death. They play important
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …
roles in cellular bioenergetics, control intracellular Ca2+ homeostasis, and participate in key …