Conventional human embryonic stem cells are considered to be primed pluripotent but can
be induced to enter a naive state. However, the transcriptional features associated with …

The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …

Human pluripotent stem cells (PSCs) exist in naive and primed states and provide important
models to investigate the earliest stages of human development. Naive cells can be …

Concerted examination of multiple collections of single-cell RNA sequencing (RNA-seq)
data promises further biological insights that cannot be uncovered with individual datasets …

Development of the early embryo takes place under low oxygen tension. Under such
conditions, the embryo implants and the trophectoderm, the outer layer of blastocyst …

Trophoblast stem cells (TSCs) have recently been derived from human embryos and early-
first-trimester placenta; however, aside from ethical challenges, the unknown disease …

Motivation The development of single-cell RNA-sequencing (scRNA-seq) provides a new
perspective to study biological problems at the single-cell level. One of the key issues in …

Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs)
obtained using independent methods differ. Naive hPSCs have been mainly derived by …

Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble
different stages of embryonic development. Naïve ESCs resemble peri-implantation stages …

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in
patterns of gene expression and developmental potential as they progress from pre …