Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Highlights•Cellular models can recapitulate some aspects of embryonic genome
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …

Embryonic stem cells (ESCs) have transcriptionally permissive chromatin enriched for gene
activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 …

Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …

Mammalian embryogenesis begins with a totipotent zygote. Blastocyst-like structures can be
captured by aggregated cells with extended pluripotent properties in a three-dimensional …