Myeloid cell-targeted therapies for solid tumours

S Goswami, S Anandhan, D Raychaudhuri… - Nature Reviews …, 2023 - nature.com
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Metabolism, metabolites, and macrophages in cancer

M Li, Y Yang, L Xiong, P Jiang, J Wang, C Li - Journal of hematology & …, 2023 - Springer
Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Control of tumor-associated macrophage responses by nutrient acquisition and metabolism

X Zhang, L Ji, MO Li - Immunity, 2023 - cell.com
Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy

X Pan, Q Zhu, LL Pan, J Sun - Pharmacology & therapeutics, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …

[HTML][HTML] Lipid metabolism, disorders and therapeutic drugs–review

V Natesan, SJ Kim - Biomolecules & therapeutics, 2021 - ncbi.nlm.nih.gov
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different
lipids are involved in the metabolic functions that play various vital roles in the body, such as …

Interaction between chronic endometritis caused endometrial microbiota disorder and endometrial immune environment change in recurrent implantation failure

P Chen, P Chen, Y Guo, C Fang, T Li - Frontiers in Immunology, 2021 - frontiersin.org
Objective To investigate the Interaction between chronic endometritis (CE) caused
endometrial microbiota disorder and endometrial immune environment change in recurrent …

[HTML][HTML] Regulation of innate immunity by Nrf2

D van der Horst, ME Carter-Timofte… - Current Opinion in …, 2022 - Elsevier
The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

Metformin, macrophage dysfunction and atherosclerosis

X Feng, W Chen, X Ni, PJ Little, S Xu, L Tang… - Frontiers in …, 2021 - frontiersin.org
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Z Su, C Li, H Wang, M Zheng, Q Chen - Journal of Translational Medicine, 2023 - Springer
Background Inflammation and immune dysfunction with classically activated macrophages
(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS) …