The increase in life expectancy without a decrease in the years lived without disability leads
to the rise of the population aged over 65 years prone to polypharmacy. The novel …

Diabetic cardiomyopathy (DCM) is the leading cause of death worldwide, and oxidative
stress was discovered to serve an important role in the pathophysiology of the condition. An …

Hypertrophic stress-induced cardiac remodeling is a compensatory mechanism associated
with cardiomyocyte hypertrophy and cardiac fibrosis. Continuation of this response …

Background Emerging evidence demonstrated dapagliflozin (DAPA), a sodium-glucose
cotransporter 2 inhibitor, prevented various cardiovascular events. However, the detailed …

Guideline-directed medical therapy (GDMT) is the cornerstone of pharmacological therapy
for patients with heart failure with reduced ejection fraction (HFrEF) and consists of the four …

Cardiovascular diseases (CVD) are a global health concern, affecting millions of patients
worldwide and being the leading cause of global morbidity and mortality, thus creating a …

As a sodium-glucose transporter 2 inhibitor (SGLT2i), the cardioprotective benefits of
Dapagliflozin (DAPA) are now widely appreciated. However, the underlying mechanism of …

Хроническая сердечная недостаточность (ХСН) и сахарный диабет 2 типа (СД2)
представляют собой важные мультидисциплинарные проблемы как по отдельности …

Abstract Purpose of Review Heart failure with preserved ejection fraction (HFpEF) imposes a
significant burden on society and healthcare. The lack in efficacious therapies is likely due to …

Background: Despite recommendations from clinical practice guidelines to initiate and titrate
guideline-directed medical therapy (GDMT) during their hospitalization, patients with acute …