Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Post-translational protein acetylation: an elegant mechanism for bacteria to dynamically regulate metabolic functions
Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …
to an existing proteome. The large number of known PTMs highlights the many ways that …
The EcoCyc database in 2021
IM Keseler, S Gama-Castro, A Mackie… - Frontiers in …, 2021 - frontiersin.org
The EcoCyc model-organism database collects and summarizes experimental data for
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual …
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual …
Protein acetylation and deacetylation: An important regulatory modification in gene transcription
C Xia, Y Tao, M Li, T Che, J Qu - Experimental and …, 2020 - spandidos-publications.com
Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …
the function of proteins is regulated by post‑translational modifications (PTMs). The …
Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom
HM Amemiya, J Schroeder, PL Freddolino - Transcription, 2021 - Taylor & Francis
Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …
all domains of life. While many of the key components and mechanisms of eukaryotic …
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation
WV Bienvenut, A Brünje, JB Boyer… - Molecular Systems …, 2020 - embopress.org
Protein acetylation is a highly frequent protein modification. However, comparatively little is
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease
Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes,
regulates various microbial metabolic pathways. However, no studies have examined …
regulates various microbial metabolic pathways. However, no studies have examined …
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases
DW Christianson - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The zinc-dependent histone deacetylases (HDACs 1–11) belong to the
arginase-deacetylase superfamily of proteins, members of which share a common α/β fold …
arginase-deacetylase superfamily of proteins, members of which share a common α/β fold …
Orthogonal Translation for Site-Specific Installation of Post-translational Modifications
Q Gan, C Fan - Chemical Reviews, 2024 - ACS Publications
Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …
environmental changes or growth needs. With the development of advanced proteomics …
Dynamic changes in the bacterial community and metabolic profile during fermentation of low-salt shrimp paste (terasi)
Low-salt shrimp paste, or terasi, is an Indonesian fermented food made from planktonic
shrimp mixed with a low concentration of salt. Since high daily intake of sodium is deemed …
shrimp mixed with a low concentration of salt. Since high daily intake of sodium is deemed …