Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained
by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Chemical modifications of histones and DNA, such as histone methylation, histone
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …