Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of
epithelial cells must establish a selectively permeable barrier that supports nutrient …

The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

The intestinal tract is the largest barrier between a person and the environment. In this role,
the intestinal tract is responsible not only for absorbing essential dietary nutrients, but also …

Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …

Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …