Sex differences in the expression of hepatic drug metabolizing enzymes
DJ Waxman, MG Holloway - Molecular pharmacology, 2009 - ASPET
Sex differences in pharmacokinetics and pharmacodynamics characterize many drugs and
contribute to individual differences in drug efficacy and toxicity. Sex-based differences in …
contribute to individual differences in drug efficacy and toxicity. Sex-based differences in …
Cytochrome P450 1 family and cancers
RE Go, KA Hwang, KC Choi - The Journal of steroid biochemistry and …, 2015 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …
Drug-metabolizing cytochrome P450 enzymes have multifarious influences on treatment outcomes
Y Song, C Li, G Liu, R Liu, Y Chen, W Li, Z Cao… - Clinical …, 2021 - Springer
Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
Drug interactions with herbal medicines
S Shi, U Klotz - Clinical pharmacokinetics, 2012 - Springer
In recent years, the issue of herbal medicine-drug interactions has generated significant
concern. Such interactions can increase the risk for an individual patient, especially with …
concern. Such interactions can increase the risk for an individual patient, especially with …
Biomarkers of oxidative stress and damage in human populations exposed to arsenic
Arsenic (As) is an ubiquitous element in the environment for which the main route of human
exposure is through consumption of drinking water. Reactive oxygen species generation …
exposure is through consumption of drinking water. Reactive oxygen species generation …
Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—persistent pollutants affect programmed cell death
M Chopra, D Schrenk - Critical reviews in toxicology, 2011 - Taylor & Francis
Exogenous ligands of the aryl hydrocarbon receptor (AhR) such as 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) and related substances are highly toxic pollutants …
tetrachlorodibenzo-p-dioxin (TCDD) and related substances are highly toxic pollutants …
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
J Terc, A Hansen, L Alston, SA Hirota - European journal of pharmaceutical …, 2014 - Elsevier
The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …
The role of drug-drug interactions in prostate cancer treatment: focus on abiraterone acetate/prednisone and enzalutamide
Elderly patients with cancer may have comorbidities, each requiring additional
pharmacologic treatment. Therefore, the occurrence of pharmacokinetic (PK) and …
pharmacologic treatment. Therefore, the occurrence of pharmacokinetic (PK) and …
Accumulation, detoxification, and toxicity of dibutyl phthalate in the swimming crab
Y He, W Lin, C Shi, R Li, C Mu, C Wang, Y Ye - Chemosphere, 2022 - Elsevier
Dibutyl phthalate (DBP) is one of the most commonly used and toxic phthalate esters and
has a variety of harmful effects on aquatic animals. However, there is still a lack of …
has a variety of harmful effects on aquatic animals. However, there is still a lack of …
Epigenetic mechanisms contribute to intraindividual variations of drug metabolism mediated by cytochrome P450 enzymes
Significant interindividual and intraindividual variations on cytochrome P450 (CYP)-
mediated drug metabolism exist in the general population globally. Genetic polymorphisms …
mediated drug metabolism exist in the general population globally. Genetic polymorphisms …