The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory
responses that promote the rapid clearance of pathogens but also contribute to pathology in …

Programs defining tissue-resident macrophage identity depend on local environmental
cues. For alveolar macrophages (AMs), these signals are provided by immune and …

Advances in cell-fate mapping have revealed the complexity in phenotype, ontogeny and
tissue distribution of the mammalian myeloid system. To capture this phenotypic diversity …

Alveolar macrophages (AM) are critical for defense against bacterial and fungal infections.
However, a definitive role of AM in viral infections remains unclear. We here report that AM …

Bone-marrow transplantation is an effective cell therapy but requires myeloablation, which
increases infection risk and mortality. Recent lineage-tracing studies documenting that …

During systemic infection and inflammation, immune effector cells are in high demand and
are rapidly consumed at sites of need. Although adaptive immune cells have high …

Summary GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells
(DCs) and is thought to control the development of inflammatory DCs and resident CD103+ …

Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth
factor receptors. A targeted inactivation of Jak2 was performed. Jak2−/− embryos are anemic …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …