Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

The effect of β-carotene, tocopherols and ascorbic acid as anti-oxidant molecules on human and animal in vitro/in vivo studies: A review of research design and …

K Miazek, K Beton, A Śliwińska, B Brożek-Płuska - Biomolecules, 2022 - mdpi.com
Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and
functioning, and is associated with the development of numerous disorders. Naturally …

Nuclear and radiological emergencies: biological effects, countermeasures and biodosimetry

E Obrador, R Salvador-Palmer, JI Villaescusa… - Antioxidants, 2022 - mdpi.com
Atomic and radiological crises can be caused by accidents, military activities, terrorist
assaults involving atomic installations, the explosion of nuclear devices, or the utilization of …

Molecular pathways associated with oxidative stress and their potential applications in radiotherapy

R Liu, Y Bian, L Liu, L Liu, X Liu… - … Journal of Molecular …, 2022 - spandidos-publications.com
Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …

The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma

DJ Hurley, C Normile, M Irnaten, C O'Brien - Antioxidants, 2022 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

Evolutionary formation of melatonin and vitamin D in early life forms: Insects take centre stage

TK Kim, RM Slominski, E Pyza… - Biological …, 2024 - Wiley Online Library
Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole
backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi …

Radiation-induced liver disease: Beyond DNA damage

YJ Zhou, Y Tang, SJ Liu, PH Zeng, L Qu, QC Jing… - Cell Cycle, 2023 - Taylor & Francis
Radiation-induced liver disease (RILD), also known as radiation hepatitis, is a serious side
effect of radiotherapy (RT) for hepatocellular carcinoma. The therapeutic dose of RT can …

Oxidative stress and radioiodine treatment of differentiated thyroid cancer

A Buczyńska, I Sidorkiewicz, M Rogucki, K Siewko… - Scientific reports, 2021 - nature.com
It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally
upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on …

Molecular hydrogen as a potential clinically applicable radioprotective agent

S Hirano, Y Ichikawa, B Sato, H Yamamoto… - International Journal of …, 2021 - mdpi.com
Although ionizing radiation (radiation) is commonly used for medical diagnosis and cancer
treatment, radiation-induced damages cannot be avoided. Such damages can be classified …

Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li… - Biomaterials, 2023 - Elsevier
There is an urgent medical need to develop effective therapies that can ameliorate damage
to the radiation-exposed hematopoietic system. Nanozymes with robust antioxidant …