Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Over the next decade, the primary challenge in human genetics will be to understand the
biological mechanisms by which genetic variants influence phenotypes, including disease …

Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …

The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …

The omnigenic model was proposed as a framework to understand the highly polygenic
architecture of complex traits revealed by genome-wide association studies (GWASs). I …

With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently …

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic
basis remains largely unresolved. We present a maternal genome-wide meta-analysis of …

Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …