Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …

Tissue-specific transcriptional regulation is central to human disease. To identify regulatory
DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted …

Twin studies are powerful tools to discriminate whether a complex disease is due to genetic
or environmental factors. High concordance rates among monozygotic (MZ) twins support …

Several genome‐wide association studies (GWAS) have been published on various
complex diseases. Although, new loci are found to be associated with these diseases, still …

Besides the effects on peripheral energy homeostasis, insulin also has an important role in
ovarian function. Obesity has a negative effect on fertility, and may play a role in the …

Hundreds of research and review articles concerning genome-wide association study
(GWAS) in diabetes have been published in the last two decades. We aimed to evaluate the …

Abstract The TALLYHO/Jng (TH) mouse strain is a polygenic model for type 2 diabetes
(T2D) characterized by moderate obesity, impaired glucose tolerance and uptake, insulin …

Syndromic adiposity appears to have a predisposition to run in families suggesting a
hereditary element in its transmission. Purely genetic defects and DNA sequence variants …