[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

M Caskey, F Klein, MC Nussenzweig - Nature medicine, 2019 - nature.com
Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z Wang, F Schmidt, Y Weisblum, F Muecksch… - Nature, 2021 - nature.com
Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers
who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2) vaccine against …

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Y Xiang, S Nambulli, Z Xiao, H Liu, Z Sang, WP Duprex… - Science, 2020 - science.org
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …

Prolonged viral suppression with anti-HIV-1 antibody therapy

C Gaebler, L Nogueira, E Stoffel, TY Oliveira, G Breton… - Nature, 2022 - nature.com
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is
effective but requires lifelong drug administration owing to a stable reservoir of latent …

[HTML][HTML] SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

E Andreano, G Piccini, D Licastro, L Casalino… - BioRxiv, 2020 - ncbi.nlm.nih.gov
To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated
authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The …

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

E Andreano, G Piccini, D Licastro… - Proceedings of the …, 2021 - National Acad Sciences
To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing …

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

JD Gunst, MH Pahus, M Rosás-Umbert, IN Lu… - Nature medicine, 2022 - nature.com
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial

JD Gunst, JF Højen, MH Pahus, M Rosás-Umbert… - Nature Medicine, 2023 - nature.com
Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human
immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double …

Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial

B Julg, KE Stephenson, K Wagh, SC Tan, R Zash… - Nature medicine, 2022 - nature.com
HIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral
escape, indicating that at least a triple bNAb therapy may be needed for robust suppression …