ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …

Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a
major global health concern associated with the emergence of new β-lactamases (BLAs) as …

Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

Abstract Metallo-β-lactamases (MBLs) represent an increasingly serious threat to public
health because of their increased prevalence worldwide in relevant opportunistic Gram …

Bacterial resistance to the majority of clinically used β-lactam antibiotics is a global health
threat and, consequently, the driving force for the development of metallo-β-lactamase …

The bacterial infection mediated by β-lactamases MβLs and SβLs has grown into an
emergent health threat, however, development of a molecule that dual inhibits both MβLs …

Elemental sulfur enables the convenient formation of C–S bonds and the direct incoporation
of S–S bonds. The reactivity of easily accessible electron deficient alkenes towards sulfur …

β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding
proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A …

New Delhi metallo-β-lactamase 1 (NDM-1) is an important causative factor of antimicrobial
resistance due to its efficient hydrolysis of a broad range of β-lactam compounds. The two …

Gram-negative bacteria producing metallo-β-lactamases (MβLs), which hydrolyze almost all
β-lactams, including penicillins, cephalosporins, and carbapenems, are important …