Currently, stem cells are a prominent focus of regenerative engineering research. However,
due to the limitations of commonly used stem cell sources, their application in therapy is …

Background While it is known that klotho has negative regulatory effects in a variety of
diseases such as metabolic disorders and kidney disease, the specific role of klotho in …

Introduction: This study aimed to investigate the relationship between circulating soluble
Klotho concentration and all-cause mortality in individuals with chronic kidney disease …

Ischemia/reperfusion injury (IRI) of the heart involves the activation of oxidative and
proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic and …

Traditional Chinese medicine (TCM) and Western Medicine both have shown efficacy in
treating male sexual dysfunction (MSD). The aim of this perspective paper is to discuss a …

Background The association between the systemic immune-inflammation index (SII) and the
serum soluble-Klotho concentration (pg/ml) in osteoarthritis (OA) patients is unknown. This …

Abstract Background Volatile Organic Compounds (VOCs) constitute an omnipresent
category of environmental contaminants. Numerous studies have identified associations …

Whether Klotho plays any role in hypothyroidism is unknown. This study aimed to determine
the relationship between serum Klotho levels and hypothyroidism in older adults. From the …

Background: Fibrosis is characterized by excessive extracellular matrix formation in solid
organs, disrupting tissue architecture and function. The Y-box binding protein-1 (YB-1) …

Renal tubular epithelial cells are vulnerable to stress-induced damage, including excessive
lipid accumulation and aging, with ANGPTL4 potentially playing a crucial bridging role …