Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Genetics and epigenetics in allergic rhinitis

BY Choi, M Han, JW Kwak, TH Kim - Genes, 2021 - mdpi.com
The pathogenesis of allergic rhinitis is associated with genetic, environmental, and
epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced …

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

JS Hawe, R Wilson, KT Schmid, L Zhou… - Nature …, 2022 - nature.com
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …

[HTML][HTML] Redox-related biomarkers in human cardiovascular disease-classical footprints and beyond

A Daiber, O Hahad, I Andreadou, S Steven, S Daub… - Redox Biology, 2021 - Elsevier
Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

Arsenic exposure, blood DNA methylation, and cardiovascular disease

A Domingo-Relloso, K Makhani… - Circulation …, 2022 - Am Heart Assoc
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-
related cardiovascular disease (CVD). We evaluated differentially methylated positions …

[HTML][HTML] The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases

B Zhang, H Jiang, Z Dong, A Sun, J Ge - Genes & diseases, 2021 - Elsevier
Abstract N6-methyladenosine (m6A) RNA methylation is an emerging area of epigenetics,
which is a reversible and dynamic modification mediating by 'writers'(methylase, adding …

Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents

H Cao, L Li, D Yang, L Zeng, X Yewei, B Yu… - European Journal of …, 2019 - Elsevier
Epigenetics is the study of heritable changes in gene expression without changing the DNA
sequence-a change in phenotype without a change in genotype. Epigenetic abnormalities …

The immune factors driving DNA methylation variation in human blood

J Bergstedt, SAK Azzou, K Tsuo, A Jaquaniello… - Nature …, 2022 - nature.com
Epigenetic changes are required for normal development, yet the nature and respective
contribution of factors that drive epigenetic variation in humans remain to be fully …

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

PA Dugué, CH Jung, JE Joo, X Wang, EM Wong… - Epigenetics, 2020 - Taylor & Francis
We conducted a genome-wide association study of blood DNA methylation and smoking,
attempted replication of previously discovered associations, and assessed the reversibility of …

Blood DNA methylation and incident coronary heart disease: evidence from the strong heart study

A Navas-Acien, A Domingo-Relloso, P Subedi… - JAMA …, 2021 - jamanetwork.com
Importance American Indian communities experience a high burden of coronary heart
disease (CHD). Strategies are needed to identify individuals at risk and implement …