Microneedle mediated transdermal delivery of protein, peptide and antibody based therapeutics: current status and future considerations

M Kirkby, ARJ Hutton, RF Donnelly - Pharmaceutical research, 2020 - Springer
The success of protein, peptide and antibody based therapies is evident-the
biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half …

Microneedle arrays combined with nanomedicine approaches for transdermal delivery of therapeutics

V Alimardani, SS Abolmaali, G Yousefi… - Journal of Clinical …, 2021 - mdpi.com
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal
drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule …

Enhancement strategies for transdermal drug delivery systems: Current trends and applications

D Ramadon, MTC McCrudden, AJ Courtenay… - Drug delivery and …, 2021 - Springer
Transdermal drug delivery systems have become an intriguing research topic in
pharmaceutical technology area and one of the most frequently developed pharmaceutical …

Exploiting unique features of microneedles to modulate immunity

C Edwards, SA Shah, T Gebhardt… - Advanced …, 2023 - Wiley Online Library
Microneedle arrays (MNAs) are small patches containing hundreds of short projections that
deliver signals directly to dermal layers without causing pain. These technologies are of …

Recent progress of 3D-printed microneedles for transdermal drug delivery

Q Yang, W Zhong, L Xu, H Li, Q Yan, Y She… - International journal of …, 2021 - Elsevier
Microneedles as novel transdermal drug delivery systems have lately attracted extensive
attention due to their distinguished properties, including improved patient compliance and …

[HTML][HTML] Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems

F Meng, A Hasan, MMN Babadaei, PH Kani… - Journal of Advanced …, 2020 - Elsevier
Background Microscopic patches as quite promising platforms in transdermal drug delivery
suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging …

[HTML][HTML] Microarray patches enable the development of skin-targeted vaccines against COVID-19

E Korkmaz, SC Balmert, TL Sumpter, CD Carey… - Advanced drug delivery …, 2021 - Elsevier
The COVID-19 pandemic is a serious threat to global health and the global economy. The
ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2 …

Vaccination into the dermal compartment: techniques, challenges, and prospects

J Hettinga, R Carlisle - Vaccines, 2020 - mdpi.com
In 2019, an 'influenza pandemic'and 'vaccine hesitancy'were listed as two of the top 10
challenges to global health by the WHO. The skin is a unique vaccination site, due to its …

Translation of polymeric microneedles for treatment of human diseases: Recent trends, Progress, and Challenges

PR Yadav, MN Munni, L Campbell, G Mostofa… - Pharmaceutics, 2021 - mdpi.com
The ongoing search for biodegradable and biocompatible microneedles (MNs) that are
strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical …

Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies

NW Kang, S Kim, JY Lee, KT Kim, Y Choi… - Expert opinion on …, 2021 - Taylor & Francis
Introduction A microneedle array patch (MAP) has been studied as a means for delivering
drugs or vaccines and has shown superior delivery efficiency compared to the conventional …