Oxidative stress and beta amyloid in Alzheimer's disease. Which comes first: the chicken or the egg?
The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …
Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials
J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
Microglia are important immune cells in the central nervous system (CNS) that undergo
turnover throughout the lifespan. If microglial debris is not removed in a timely manner …
turnover throughout the lifespan. If microglial debris is not removed in a timely manner …
Immune Activation in Alzheimer Disease
Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …
efficient curative treatment available, its medical, social, and economic burdens are …
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
CD33 isoforms in microglia and Alzheimer's disease: Friend and foe
Alzheimer's disease (AD) is the most common form of neurodegenerative disease and is
considered the main cause of dementia worldwide. Genome-wide association studies …
considered the main cause of dementia worldwide. Genome-wide association studies …
Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease
S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
Application of CRISPR/Cas9 in Alzheimer's disease
L Lu, X Yu, Y Cai, M Sun, H Yang - Frontiers in neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder
clinically characterized by cognitive impairment, abnormal behavior, and social deficits …
clinically characterized by cognitive impairment, abnormal behavior, and social deficits …
Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study
Increased expression of CD33 in the brain has been suggested to be associated with
increased amyloid plaque burden, while the peripheral level of CD33 in Alzheimer's disease …
increased amyloid plaque burden, while the peripheral level of CD33 in Alzheimer's disease …
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
S Zia, BP Hammond, M Zirngibl, A Sizov… - Molecular …, 2022 - Springer
Background Microglia regulate the response to injury and disease in the brain and spinal
cord. In white matter diseases microglia may cause demyelination. However, how microglia …
cord. In white matter diseases microglia may cause demyelination. However, how microglia …