Neuronal death in cerebral ischemia is largely due to excitotoxic mechanisms, which are
known to activate the c-Jun N-terminal kinase (JNK) pathway. We have evaluated the …

Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline:
Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation …

Background: Patients with TIA are at increased risk of ischemic stroke and require
preventive treatment. However, clinical guidelines differ on how urgently patients should be …

Induced hypothermia is proposed as a treatment for acute ischaemic stroke, but there have
been too few clinical trials involving too few patients to draw any conclusions about the …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

Plasticity phenomena in the cerebral cortex after ischemic injury have been documented
repeatedly over the past 2 decades both in animal models and in human stroke survivors …

There is currently no approved neuroprotective pharmacotherapy for acute conditions such
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …

Alteplase (rt-PA) is the first therapy successfully developed for acute stroke therapy. The
success of rt-PA spurred development of new avenues for acute stroke management. For the …

The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
is a common underlying mechanism of many neuropathologies, as they have been shown to …