Recent advances in management of transient ischaemic attacks and minor ischaemic strokes

PM Rothwell, A Buchan, SC Johnston - The Lancet Neurology, 2006 - thelancet.com
The risk of recurrent stroke during the first few days after a transient ischaemic attack or
minor stroke is much higher than previously estimated. However, there is substantial …

[HTML][HTML] Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFκB pathways in ischemic stroke

X Feng, M Li, Z Lin, Y Lu, Y Zhuang, J Lei, X Liu… - Neurochemistry …, 2023 - Elsevier
Ischemic stroke results in demyelination that underlies neurological disfunction. Promoting
oligodendrogenesis will rescue the injured axons and accelerate remyelination after stroke …

Mechanisms of ischemic brain injury

V Janardhan, AI Qureshi - Current cardiology reports, 2004 - Springer
Stroke is the third leading cause of death and the leading cause of long-term disability in the
United States. Approximately 80% of all strokes are ischemic and there are limited therapies …

Global cerebral ischemia: synaptic and cognitive dysfunction

JT Neumann, CH Cohan, KR Dave… - Current drug …, 2013 - ingentaconnect.com
Cardiopulmonary arrest is one of the leading causes of death and disability, primarily
occurring in the aged population. Numerous global cerebral ischemia animal models induce …

Mechanistic insight on autophagy modulated molecular pathways in cerebral ischemic injury: from preclinical to clinical perspective

P Kalra, H Khan, A Kaur, TG Singh - Neurochemical Research, 2022 - Springer
Cerebral ischemia is one of the most devastating brain injuries and a primary cause of
acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at …

Neurorestorative treatment of stroke: cell and pharmacological approaches

J Chen, M Chopp - NeuroRx, 2006 - Elsevier
There is a compelling need to develop cell and pharmacological therapeutic approaches to
be administered beyond the hyperacute phase of stroke. These therapies capitalize on the …

Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics

K Pong - Expert opinion on biological therapy, 2003 - Taylor & Francis
Evidence of oxidative stress is apparent in both acute and chronic neurodegenerative
diseases, such as stroke, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) …

[HTML][HTML] Nonhuman primate models of stroke for translational neuroprotection research

DJ Cook, M Tymianski - Neurotherapeutics, 2012 - Elsevier
Despite the discovery of several promising neuroprotective therapies in rodent models of
stroke, no therapy other than the fibrinolytics has been found to be effective in human clinical …

[HTML][HTML] Inflammation, plasticity and real-time imaging after cerebral ischemia

J Kriz, M Lalancette-Hébert - Acta neuropathologica, 2009 - Springer
With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death
and a major cause of disability in industrialized countries. At present, although progress has …

Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats

VA DiNapoli, JD Huber, K Houser, X Li, CL Rosen - Neurobiology of aging, 2008 - Elsevier
We examined the effects of age on stroke progression and outcome in order to explore the
association between blood–brain barrier (BBB) disruption, neuronal damage, and functional …