Background: Stroke is one of the major challenges to health and the reason for increasing
disability-adjusted life years. Despite tremendous progress in preclinical studies, none of the …

Amphetamines for improving recovery after stroke - Martinsson, L - 2007 | Cochrane Library Skip
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Ischemic stroke accounts for the majority of stroke cases and constitutes a major cause of
death and disability in the industrialized world. Inflammation has been reported to constitute …

Reactive oxygen species-induced oxidative damage remains an extensively validated
secondary injury mechanism in traumatic brain injury (TBI) as demonstrated by the efficacy …

Subcortical white matter (WM) is a frequent target of ischemic injury and extensive WM
lesions are important substrates of vascular cognitive impairment (VCI) in humans. However …

Numerous failures in clinical stroke trials have led to some pessimism in the field. This short
review examines the following questions: Can experimental models of stroke be validated …

Acute stroke is now a treatable condition that deserves urgent specialist attention. Drug
treatment and specialist care both influence survival and recovery. This article considers the …

Matrix metalloproteinases (MMPs) may contribute to the pathophysiology of cerebral
ischemia by degrading matrix components in the neurovascular unit. In this study, the …

Exendin-4 is a glucagon-like receptor 1 agonist clinically used against type 2 diabetes that
has also shown neuroprotective effects in experimental stroke models. However, while the …

Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to exert protective
effects against several neurological diseases through its anti-oxidative and anti …