Association of Genetic Risk for Age-Related Macular Degeneration with Morphological Features of the Retinal Microvascular Network

A Sendecki, D Ledwoń, A Tuszy, J Nycz, A Wąsowska… - Diagnostics, 2024 - mdpi.com
Background: Age-related macular degeneration (AMD) is a multifactorial disease
encompassing a complex interaction between aging, environmental risk factors, and genetic …

[HTML][HTML] Genetic mechanism revealed of age-related macular degeneration based on fusion of statistics and machine learning method

Y Du, N Kong, J Zhang - Frontiers in genetics, 2021 - frontiersin.org
Age-related macular degeneration (AMD) is the most common cause of irreversible vision
loss in the developed world which affects the quality of life for millions of elderly individuals …

Mitochondrial damage and clearance in retinal pigment epithelial cells

IS Gurubaran - 2024 - Wiley Online Library
Age‐related macular degeneration (AMD) is a devastating eye disease that causes
permanent vision loss in the central part of the retina, known as the macula. Patients with …

Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study

L Wang, W Wei, YJ Zhao, S Chen, D Wu… - Experimental Eye …, 2024 - Elsevier
This study aims to determine the risk associated with early age-related macular
degeneration (AMD) due to refractive errors (RE) using an analysis of genome-wide …

[HTML][HTML] Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration

R Terao, BS Sohn, T Yamamoto, TJ Lee… - … & Visual Science, 2024 - jov.arvojournals.org
Purpose: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD.
Cellular senescence contributes to the development of numerous age-associated diseases …

[HTML][HTML] ANO2 Genetic Variants and Anti-VEGF Treatment Response in Neovascular AMD: A Pharmacogenetic Substudy of VIEW 1 and VIEW 2

RH Guymer, R Silva, M Ghadessi, S Leal… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: This analysis investigated potential associations between gene variants and
clinical end points in the VIEW 1 and 2 randomized clinical trials of intravitreal aflibercept …

[HTML][HTML] Causal association between rheumatoid arthritis and an increased risk of age-related macular degeneration: A Mendelian randomization study

M Zhang, L Duan, Y Feng - Medicine, 2024 - journals.lww.com
This study's goal is to evaluate if there is a causal connection between rheumatoid arthritis
(RA) and age-related macular degeneration (AMD), despite past epidemiological studies …

[HTML][HTML] An analysis of the effect of ABCA4 p. Asn1868Ile genotypes on retinal structure in 26,558 participants in the UK Biobank

MJ Simcoe, G Arno, PG Hysi, T Ko… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: To determine whether the ABCA4 retinopathy-associated variant p. Asn1868Ile (c.
5603A> T) is associated with retinal structure or subclinical disease among the general …

Age-Related Macular Degeneration and Its Genetic Risk: A Population-based Study

D Garzone, MA Imtiaz, MM Mauschitz, NA Aziz… - Current eye …, 2024 - Taylor & Francis
Purpose Specific genetic factors might serve as markers for risk stratification of AMD
progression, but their association with key features of AMD has not been fully elucidated …

Genetic Distinctions Between Reticular Pseudodrusen and Drusen: Insights from a Genome-Wide Association Study

R Schwartz, AN Warwick, AP Khawaja, R Luben… - medRxiv, 2024 - medrxiv.org
Purpose: To explore genetic determinants specific to reticular pseudodrusen (RPD), and to
compare these with genetic associations for drusen. Setting: Participants with RPD, drusen …