Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …

The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …