The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of
ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence …

Pericytes are branched cells located in the wall of capillary blood vessels that are found
throughout the body, embedded within the microvascular basement membrane and …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …

Following lesions to the central nervous system, scar tissue forms at the lesion site. Injury
often severs axons and scar tissue is thought to block axonal regeneration, resulting in …

With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

Members of the platelet-derived growth factor (PDGF) family are well known to be involved
in different pathological conditions. The cellular and molecular mechanisms induced by the …

Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the
maintenance of brain neurovascular unit. These cells participate in brain homeostasis by …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …