Climate change is adversely affecting the burden of infectious disease throughout the world,
which is a health security threat. Climate-sensitive infectious disease includes vector-borne …

Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …

Background The candidate malaria vaccine RTS, S/AS01 is being evaluated in order to
inform a decision regarding its inclusion in routine vaccination schedules. Methods We …

Background The RTS, S/AS01 vaccine targets the circumsporozoite protein of Plasmodium
falciparum and has partial protective efficacy against clinical and severe malaria disease in …

The need to optimize vaccine potency while minimizing toxicity in healthy recipients has
motivated studies of the formulation of vaccines to control how, when, and where antigens …

Background Obesity in childhood is associated with increased cardiovascular risk. It is
uncertain whether this risk is attenuated in persons who are overweight or obese as children …

In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …

RTS, S is an advanced malaria vaccine candidate and confers significant protection against
Plasmodium falciparum infection in humans. Little is known about the molecular …