Brain aging and garbage cleaning: modelling the role of sleep, glymphatic system, and microglia senescence in the propagation of inflammaging
S Gordleeva, O Kanakov, M Ivanchenko… - Seminars in …, 2020 - Springer
Brain aging is a complex process involving many functions of our body and described by the
interplay of a sleep pattern and changes in the metabolic waste concentration regulated by …
interplay of a sleep pattern and changes in the metabolic waste concentration regulated by …
Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population
The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …
Modeling working memory in a spiking neuron network accompanied by astrocytes
We propose a novel biologically plausible computational model of working memory (WM)
implemented by a spiking neuron network (SNN) interacting with a network of astrocytes …
implemented by a spiking neuron network (SNN) interacting with a network of astrocytes …
Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network
Recent in vitro and in vivo experiments demonstrate that astrocytes participate in the
maintenance of cortical gamma oscillations and recognition memory. However, the …
maintenance of cortical gamma oscillations and recognition memory. However, the …
Trajectories, bifurcations, and pseudo-time in large clinical datasets: applications to myocardial infarction and diabetes data
Background Large observational clinical datasets are becoming increasingly available for
mining associations between various disease traits and administered therapy. These …
mining associations between various disease traits and administered therapy. These …
Epidemiological and genetic overlap among biological aging clocks: New challenges in biogerontology
Estimators of biological age (BA)–defined as the hypothetical underlying age of an organism–
have attracted more and more attention in the last years, especially after the advent of new …
have attracted more and more attention in the last years, especially after the advent of new …
Situation-based neuromorphic memory in spiking neuron-astrocyte network
Mammalian brains operate in very special surroundings: to survive they have to react quickly
and effectively to the pool of stimuli patterns previously recognized as danger. Many …
and effectively to the pool of stimuli patterns previously recognized as danger. Many …
[HTML][HTML] A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project
C Pirazzini, T Azevedo, L Baldelli… - Mechanisms of Ageing …, 2021 - Elsevier
Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the
biological relationship between PD and ageing remains elusive. Here we describe the …
biological relationship between PD and ageing remains elusive. Here we describe the …
Why we should use topological data analysis in ageing: towards defining the “topological shape of ageing”
Living systems are subject to the arrow of time; from birth, they undergo complex
transformations (self-organization) in a constant battle for survival, but inevitably ageing and …
transformations (self-organization) in a constant battle for survival, but inevitably ageing and …
Bistability and chaos emergence in spontaneous dynamics of astrocytic calcium concentration
EV Pankratova, MS Sinitsina, S Gordleeva… - Mathematics, 2022 - mdpi.com
In this work, we consider a mathematical model describing spontaneous calcium signaling
in astrocytes. Based on biologically relevant principles, this model simulates experimentally …
in astrocytes. Based on biologically relevant principles, this model simulates experimentally …