Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

J Li, J Seidlitz, J Suckling, F Fan, GJ Ji, Y Meng… - Nature …, 2021 - nature.com
Major depressive disorder (MDD) has been shown to be associated with structural
abnormalities in a variety of spatially diverse brain regions. However, the correlation …

[HTML][HTML] Comparing spatial null models for brain maps

RD Markello, B Misic - NeuroImage, 2021 - Elsevier
Technological and data sharing advances have led to a proliferation of high-resolution
structural and functional maps of the brain. Modern neuroimaging research increasingly …

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

BB Lake, S Chen, BC Sos, J Fan, GE Kaeser… - Nature …, 2018 - nature.com
Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

FL Ricklefs, Q Alayo, H Krenzlin, AB Mahmoud… - Science …, 2018 - science.org
Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1)
leads to cancer immune evasion via inhibition of T cell function. One of the defining …

Neuroscience needs network science

DL Barabási, G Bianconi, E Bullmore… - Journal of …, 2023 - Soc Neuroscience
The brain is a complex system comprising a myriad of interacting neurons, posing significant
challenges in understanding its structure, function, and dynamics. Network science has …

[HTML][HTML] BrainStat: A toolbox for brain-wide statistics and multimodal feature associations

S Larivière, Ş Bayrak, RV de Wael, O Benkarim… - NeuroImage, 2023 - Elsevier
Abstract Analysis and interpretation of neuroimaging datasets has become a
multidisciplinary endeavor, relying not only on statistical methods, but increasingly on …

Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19

J Davies, HS Randeva, K Chatha… - Molecular …, 2020 - spandidos-publications.com
Infection by the severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) is
the cause of the new viral infectious disease (coronavirus disease 2019; COVID‑19) …

Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse

Y Zhang, SA Sloan, LE Clarke, C Caneda, CA Plaza… - Neuron, 2016 - cell.com
The functional and molecular similarities and distinctions between human and murine
astrocytes are poorly understood. Here, we report the development of an immunopanning …

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

JB Burt, M Demirtaş, WJ Eckner, NM Navejar, JL Ji… - Nature …, 2018 - nature.com
Hierarchy provides a unifying principle for the macroscale organization of anatomical and
functional properties across primate cortex, yet microscale bases of specialization across …

Scaling single-cell genomics from phenomenology to mechanism

A Tanay, A Regev - Nature, 2017 - nature.com
Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …