Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Nervous systems are composed of various cell types, but the extent of cell type diversity is
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …

Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …

The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …

Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …

Humans display reproducible sex differences in cognition and behavior, which may partly
reflect intrinsic sex differences in regional brain organization. However, the consistency …

Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-
HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific …

The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into
adulthood; however, the relationship between developmental and adult dentate gyrus …