Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Glutamine-dependent amidotransferases have been known for more than 30 years. The
mechanism by which these enzymes generate ammonia from the glutamine amide nitrogen …

Codon usage data has been compiled for 110 yeast genes. Cluster analysis on relative
synonymous codon usage revealed two distinct groups of genes. One group corresponds to …

Multiwavelength anomalous diffraction (MAD) has been used to determine the structure of
the regulatory enzyme of de novo synthesis of purine nucleotides, glutamine 5 …

The budding yeast Saccharomyces cerevisiae responds to depletion of iron in the
environment by activating Aft1p, the major iron-dependent transcription factor, and by …

An approximately 16-kilobase pair region of the Bacillus subtilis chromosome at 55 degrees
containing genes for de novo purine nucleotide synthesis (Piggot, PJ, and Hoch, JA (1985) …

We have compared the translational initiator regions of 131 yeast genes. 95% utilize the first
AUG from the 5′ end of the message as the start codon for translation. Yeast leader regions …

Glutamine amidotransferases are a family of enzymes that utilize the amide of glutamine in
the biosynthesis of amino acids, purine and pyrimidine nucleotides, amino sugars …

We have found cross-pathway regulation between purine and histidine biosynthesis in
yeast. The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the …

Phosphoribosylpyrophosphate (P-Rib-PP) synthetase of Escherichia coli has been purified
to near homogeneity from a strain harboring the prs gene, encoding P-Rib-PP synthetase …