Alterations in gut microbiota of abdominal aortic aneurysm mice

J Xie, W Lu, L Zhong, Y Hu, Q Li, R Ding… - BMC cardiovascular …, 2020 - Springer
Background The gut microbiome plays an important role in various cardiovascular diseases,
such as atherosclerosis and hypertension, which are associated with abdominal aortic …

The water chemistry and microbiome of household wells in Medawachchiya, Sri Lanka, an area with high prevalence of chronic kidney disease of unknown origin …

LK McDonough, KT Meredith, C Nikagolla… - Scientific Reports, 2020 - nature.com
Chronic kidney disease (CKD) of unknown etiology (CKDu) mostly affects agricultural
communities in Central America, South Asia, Africa, but likely also in North America and …

[HTML][HTML] Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut

E Jameson, M Quareshy, Y Chen - Methods, 2018 - Elsevier
The bacterial formation of trimethylamine (TMA) has been linked to cardiovascular disease.
This review focuses on the methods employed to investigate the identity of the bacteria …

Serum gut microbe-dependent trimethylamine N-oxide improves the prediction of future cardiovascular disease in a community-based general population

L Zheng, J Zheng, Y Xie, Z Li, X Guo, G Sun, Z Sun… - Atherosclerosis, 2019 - Elsevier
Background and aims Recent studies have shown that trimethylamine N-oxide (TMAO) is a
risk factor for cardiovascular disease (CVD) in different clinical settings, but few studies …

[HTML][HTML] Immunosenescence, gut dysbiosis, and chronic kidney disease: interplay and implications for clinical management

TH Lee, JJ Chen, CY Wu, TY Lin, SC Hung, HY Yang - Biomedical Journal, 2023 - Elsevier
Immunosenescence refers to the immune system changes observed in individuals over 50
years old, characterized by diminished immune response and chronic inflammation. Recent …

Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

T Ebert, J Painer, P Bergman, AR Qureshi, S Giroud… - Scientific Reports, 2020 - nature.com
Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the
aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via …

Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease

Y Li, M Dai, J Yan, F Liu, X Wang, L Lin, M Huang… - Scientific Reports, 2021 - nature.com
Chronic kidney disease (CKD) is a major public health burden around the world. The gut
microbiome may contribute to CKD progression and serve as a promising therapeutic target …

The Effect of Inulin‐Type Fructans on Plasma Trimethylamine N‐Oxide Levels in Peritoneal Dialysis Patients: A Randomized Crossover Trial

Q Xiong, L Li, Y Xiao, S He, J Zhao… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Trimethylamine N‐oxide (TMAO), an important proatherogenic uremic toxin, is
oxidized by hepatic‐flavin monooxygenases from gut microbiome‐generated trimethylamine …

Metabolic abnormalities in diabetes and kidney disease: role of uremic toxins

L Koppe, D Fouque, CO Soulage - Current Diabetes Reports, 2018 - Springer
Abstract Purpose of Review Chronic kidney disease (CKD) is characterized by the
accumulation of uremic retention solutes (URS) and is associated with perturbations of …

Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study

S Yan, H Wang, B Feng, L Ye, A Chen - Frontiers in Immunology, 2024 - frontiersin.org
Objective Emerging evidence has provided compelling evidence linking gut microbiota (GM)
and diabetic nephropathy (DN) via the “gut-kidney” axis. But the causal relationship between …