PCSK9 inhibition during the inflammatory stage of SARS-CoV-2 infection

EP Navarese, P Podhajski, PA Gurbel… - Journal of the American …, 2023 - jacc.org
Background The intensity of inflammation during COVID-19 is related to adverse outcomes.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in low-density lipoprotein …

A phenome‐wide investigation of risk factors for severe COVID‐19

A Baranova, H Cao, S Teng… - Journal of Medical …, 2023 - Wiley Online Library
With the continued spread of COVID‐19 globally, it is crucial to identify the potential risk or
protective factors associated with COVID‐19. Here, we performed genetic correlation …

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

A Giannella, S Riccetti, A Sinigaglia, C Piubelli… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 induces a spectrum of clinical conditions ranging from
asymptomatic infection to life threatening severe disease. Host microRNAs have been …

D-dimer: old dogmas, new (COVID-19) tricks

G Lippi, F Mullier, EJ Favaloro - Clinical Chemistry and Laboratory …, 2023 - degruyter.com
D-dimer is a fibrin degradation product encompassing multiple cross-linked D domains
and/or E domains present in the original fibrinogen molecule, whose generation is only …

Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence

JS Gisby, NB Buang, A Papadaki, CL Clarke… - Nature …, 2022 - nature.com
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here,
we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19 …

MIL-101 (CuFe) Nanozymes with excellent peroxidase-like activity for simple, accurate, and visual naked-eye detection of SARS-CoV-2

X Zhao, Z Yang, R Niu, Y Tang, H Wang… - Analytical …, 2022 - ACS Publications
The COVID-19 pandemic has spread to every corner of the world and seriously affected our
health and daily activities in the past three years; thereby, it is still urgent to develop various …

Microvascular thrombosis as a critical factor in severe COVID-19

PP Wadowski, B Panzer, A Józkowicz… - International Journal of …, 2023 - mdpi.com
Platelet–endothelial interactions have a critical role in microcirculatory function, which
maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall …

Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

KC Marques, JAS Quaresma… - Frontiers in cardiovascular …, 2023 - frontiersin.org
Long COVID is characterized by persistent signs and symptoms that continue or develop for
more than 4 weeks after acute COVID-19 infection. Patients with Long COVID experience a …

Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement

M Sayyadi, S Hassani, M Shams, A Dorgalaleh - Annals of Hematology, 2023 - Springer
The coagulation, fibrinolytic, anticoagulation, and complement systems are in delicate
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …

The role of platelet P2Y12 receptors in inflammation

WAE Parker, RF Storey - British Journal of Pharmacology, 2024 - Wiley Online Library
Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …