Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the
irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine …

The uptake of nucleosides (or nucleobases) is essential for nucleic acid synthesis in many
human cell types and in parasitic organisms that cannot synthesize nucleotides de novo …

Abstract Ischemia/reperfusion (I/R) injury associated with hepatic resections and liver
transplantation remains a serious complication in clinical practice, despite several attempts …

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the
onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective …

Numerous studies have consistently shown that agonist stimulation of adenosine A1
receptors results in a significant reduction of morbidity and mortality associated with global …

Background: Remote ischemic preconditioning (RIPC) may confer the protection in critical
organs. The authors hypothesized that limb RIPC would reduce lung injury in patients …

Ischemic preconditioning refers to the endogenous mechanism of protection against a
sustained ischemic insult following an initial, brief ischemic stimulus. Ischemia-reperfusion …

Objective: Prolonged limb ischemia followed by reperfusion (I/R) is associated with a
systemic inflammatory response syndrome and remote acute lung injury. Ischemic …

Physical exercise promotes beneficial health effects by preventing or reducing the
deleterious effects of pathological conditions, such as arterial hypertension, coronary artery …