Allogeneic hematopoietic cell transplantation (HCT) following nonmyeloablative
conditioning has been extensively evaluated in patients with hematologic malignancies who …

Hematopoietic stem cell transplantation (HSCT) is the definitive cure for many malignant and
nonmalignant diseases. However, delays in immune reconstitution (IR) following HSCT …

Virus-specific T cells have proven highly effective for the treatment of severe and drug-
refractory infections after hematopoietic stem cell transplant (HSCT). However, the efficacy of …

CD4 T cells, particularly those of the T-helper 1 (Th1) subset, are important effectors in
alloimmune diseases, such as graft-versus-host disease, and in controlling infections with …

Acute graft-versus-host disease (GVHD) is a life-threatening complication following bone
marrow transplantation; however, no effective molecular-targeting therapy has been …

Posttranslational modification with SUMO is known to regulate the activity of transcription
factors, but how SUMOylation of individual proteins might influence immunity is largely …

Allogeneic hematopoietic cell transplantation (HCT) after myeloablative conditioning
regimens has been an effective treatment for many patients with hematologic malignancies …

Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies
and severe autoimmune diseases. Graft versus host disease (GVHD) is the major …

Cannabidiol (CBD) is a highly lipidic phytocannabinoid with remarkable anti-inflammatory
effects. The aim of this study was to evaluate CBD's effects and mechanisms of action in the …

We enrolled 11 patients with refractory graft-versus-host disease (GVHD) in a prospective
trial evaluating the efficacy of mycophenolate mofetil (MMF). Four (67%) of the 6 patients …