Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …