Assessing the mitochondrial safety profile of the molnupiravir active metabolite, β-d-N4-hydroxycytidine (NHC), in the physiologically relevant HepaRG model

RT Kiy, SH Khoo, AE Chadwick - Toxicology Research, 2024 - academic.oup.com
Abstract Background β-d-N4-Hydroxycytidine (NHC) is the active metabolite of molnupiravir,
a broad-spectrum antiviral approved by the MHRA for COVID-19 treatment. NHC induces …

Simple Green Spectrophotometric & Chromatographic Assay of the oral antiviral treatment of COVID-19: Molnupiravir-EIDD-2801

M Abdel Moneim, M Kamal… - Egyptian Journal of …, 2023 - ejchem.journals.ekb.eg
Although vaccination for “Coronavirus disease 2019” is currently available, effective antiviral
therapy is of great importance. The presence of easily administrated oral antivirals was a …

[HTML][HTML] Molnupiravir for treating COVID‐19

EA Ochodo, E Owino, B Nyagol, T Fox… - The Cochrane …, 2022 - ncbi.nlm.nih.gov
Molnupiravir for treating COVID‐19 - PMC Back to Top Skip to main content NIH NLM Logo
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Preview …

[HTML][HTML] Ritonavir-boosted Nirmatrelvir and COVID-19 outcomes in the age of Omicron variant

L Imran, R Zubair, S Mughal… - Annals of Medicine and …, 2023 - journals.lww.com
Nirmatrelvir boosted with Ritonavir is the recommended and preferred treatment for COVID-
19. Because real-world evidence of Nirmatrelvir's antiviral activity against the Omicron …

A mini-review on clinical studies of Molnupiravir for COVID-19 conducted in selected Asian countries

JMB Querequincia, EM Faller - GSC Biological and …, 2022 - gsconlinepress.com
The key goal of this mini review article is to provide enough data and info on the several
clinical trials conducted in some number of countries in the Asia on the use of the drug …

[HTML][HTML] The MEK1/2 inhibitor ATR-002 (Zapnometinib) synergistically potentiates the antiviral effect of direct-acting anti-SARS-coV-2 drugs

A Schreiber, B Ambrosy, O Planz, S Schloer… - Pharmaceutics, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) represents a global public health burden. In
addition to vaccination, safe and efficient antiviral treatment strategies to restrict the viral …

Efficacy of Lactococcus lactis strain plasma (LC-Plasma) in easing symptoms in patients with mild COVID-19: protocol for an exploratory, multicentre, double-blinded …

K Yamamoto, N Hosogaya, T Inoue, K Jounai, R Tsuji… - BMJ open, 2022 - bmjopen.bmj.com
Introduction The COVID-19 pandemic has been a major concern worldwide; however, easily
accessible treatment options for patients with mild COVID-19 remain limited. Since the oral …

[HTML][HTML] Unravelling Insights into the Evolution and Management of SARS-CoV-2

AGA Mushebenge, SC Ugbaja, NA Mbatha, RB Khan… - …, 2024 - mdpi.com
Worldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2,
has claimed a sizable number of lives. The virus' rapid spread and impact on every facet of …

[HTML][HTML] Plant-derived Ren's oligopeptide has antiviral effects on influenza virus and SARS-CoV-2

C Yu, Y Huang, X Ren, L Sun - Frontiers in veterinary science, 2023 - frontiersin.org
Influenza virus and SARS-CoV-2 virus are two important viruses that cause respiratory tract
diseases. The high-frequency mutation of the two types of viruses leads to failure of the …

Oral anti-COVID-19 drugs that were recently evaluated by FDA or EMA: a review

D Lorenz, R Pawliczak - Alergologia Polska-Polish Journal of …, 2022 - termedia.pl
COVID-19 is an infectious disease that is caused by coronavirus SARS-CoV-2. As the time
passed it became clear that, aside from the vaccines, other efficient methods of fighting the …