Background Analysing genomes of animal model organisms is widely used for
understanding the genetic basis of complex traits and diseases, such as obesity, for which …

Rare and undiagnosed diseases substantially decrease patient quality of life and have
increasingly become a heavy burden on healthcare systems. Because of the challenges in …

Background Our previous research identified the Kruppel like factor 6 (KLF6) gene as a
prospective candidate for milk production traits in dairy cattle. The expression of KLF6 in the …

Urinary stone disease (USD) is a major health burden affecting> 10% of the UK population
at some time. While stone disease is strongly associated with lifestyle, genetic factors also …

Background Clonal haematopoiesis (CH) is an age-associated clonal expansion of blood
cells driven by leukaemia-associated somatic mutations. Although CH has been reported to …

Many molecular approaches have been employed for the quality control (QC) of biobanked
DNA samples. Since 2003, the National Biobank of Korea (NBK) has provided various …

Background Genome-wide association studies for glycemic traits have identified hundreds
of loci associated with these biomarkers of glucose homeostasis. Despite this success, the …

Genetic association studies have focused on testing additive models in cohorts with
European ancestry. Little is known about recessive effects on common diseases, specifically …

Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In
this genetic and proteomic study, we expand the number of genetic loci from 19 to 29, and …

Nucleic acids are paving the way for advanced therapeutics. Unveiling the genome enabled
a better understanding of unique genotype–phenotype profiling. Methods for engineering …