Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently
absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a …

Irritable bowel syndrome (IBS) is a common disorder characterized by altered gut function
and often is accompanied by comorbid anxiety. Although changes in the gut microbiota have …

Natural dietary agents have attracted considerable attention due to their role in promoting
health and reducing the risk of diseases including cancer. Ginger, one of the most ancient …

Background The intestinal mucosa is composed of a well-organized epithelium, acting as a
physical barrier to harmful luminal contents, while simultaneously ensuring absorption of …

A single layer of enterocytes and tight junctions (intercellular multiprotein complexes) form
the intestinal epithelial barrier that controls transport of molecules through transcellular and …

Background & Aims Defects in the epithelial tight junction (TJ) barrier contribute to
development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) …

Background & Aims Emerging data suggest that changes in intestinal permeability and
increased gut microbial translocation contribute to the inflammatory pathway involved in …

Defective epithelial barrier function is present in maladies including epidermal burn injury,
environmental lung damage, renal tubular disease, and a range of immune-mediated and …