Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages

S Wu, J Liao, G Hu, L Yan, X Su, J Ye, C Zhang… - Biochemical …, 2023 - Elsevier
Sepsis is a dysregulated systemic inflammatory response caused by infection that leads to
multiple organ injury and high mortality without effective treatment. Corilagin, a natural …

Mechanisms and therapeutic strategies for MAFLD targeting TLR4 signaling pathways

G Ren, C Bai, S Yi, Q Cong, Y Zhu - Innate Immun, 2024 - karger.com
Background: Metabolic-associated fatty liver disease (MAFLD) is one of the most common
chronic liver diseases. The underlying pathophysiological mechanisms are intricate and …

[HTML][HTML] Role of pattern recognition receptors in the development of MASLD and potential therapeutic applications

L Yu, F Gao, Y Li, D Su, L Han, Y Li, X Zhang… - Biomedicine & …, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the
most prevalent liver diseases worldwide, and its occurrence is strongly associated with …

Bifidobacterium breve CCFM1310 enhances immunity in immunosuppressed mice via modulating immune response and gut microbiota

H Fang, H Li, Y Chen, X Liu, J Zhao, P Ross, C Stanton… - Food Bioscience, 2024 - Elsevier
There has been a rising interest in studying how Bifidobacterium breve can affect the
immune system over the years. The aim of this study was to evaluate the effect of B. breve on …

Jian‐Pi‐Gu‐Shen‐Hua‐Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis

S Lv, L Fan, X Chen, X Su, L Dong… - Journal of Diabetes …, 2024 - Wiley Online Library
Background. Diabetic nephropathy (DN), one of the most frequent complications of diabetes
mellitus, is a leading cause of end‐stage renal disease. However, the current treatment …

Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway‐Mediated Apoptosis and …

T Zhang, W Sun, L Wang, H Zhang… - Journal of Diabetes …, 2023 - Wiley Online Library
Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers
various renal cell dysfunctions, eventually leading to progressive kidney failure. Rosa …

Hedan tablet ameliorated non‐alcoholic steatohepatitis by moderating NF‐κB and lipid metabolism‐related pathways via regulating hepatic metabolites

L Guo, J Lei, P Li, Y Wang, J Wang… - Journal of Cellular …, 2024 - Wiley Online Library
Non‐alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease. If not treated, it
can lead to liver damage, cirrhosis and even liver cancer. However, advances in treatment …

Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics

Y Yang, J Liu, H Ou, X Ma, J Li, B Shao… - Evidence‐Based …, 2023 - Wiley Online Library
Background. With the continuous advancement of clinical application and experimental
research of JTP, the application prospect of JTP in nervous system diseases and metabolic …