Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Recognition of pathogen-derived molecules by pattern recognition receptors (PRRs) is a
common feature of both animal and plant innate immune systems. In plants, PRR signalling …

Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

Abstract Families of innate immune receptors serve as the bodies primary defence system
by recognising and rapidly responding to infection by microorganisms or to endogenous …

Gain-of-function mutations in LRRK2, which encodes the leucine-rich repeat kinase 2
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …

We here attempt to achieve an integrated understanding of the structure and dynamics of a
number of higher-order assemblies, including amyloids, various kinds of signalosomes, and …

Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute
myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been …