Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

Identified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly
proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived …

Malaria is one of the most significant causes of childhood mortality, but disease control
efforts are threatened by resistance of the Plasmodium parasite to current therapies …

New antiparasitic drugs are urgently needed to treat and control diseases such as malaria,
leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year …

Lead discovery is currently a key bottleneck in the pipeline for much-needed novel drugs for
tropical diseases such as malaria, tuberculosis, African sleeping sickness, leishmaniasis …

The origin of all mitochondria can be traced to the symbiotic arrangement that resulted in the
emergence of eukaryotes in a world that was exclusively populated by prokaryotes,,. This …

Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the
development of resistance. In an effort to identify new potential antimalarials, we have …

Despite being one of the most prevalent tropical diseases, for many years malaria was not a
commercial priority for the pharmaceutical industry. However, in response to the emergence …

Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …