The link between inflammation and cancer was first proposed by R. Virchow. It was later
realized that it is chronic inflammation that may promote cancer, whereas acute inflammation …

Blood platelets are here presented as active players in antimicrobial host defense and the
induction of inflammation and tissue repair in addition to their participation in hemostasis …

Acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow
transplantation (BMT), limits the application of this curative but toxic therapy. Studies of …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …

The intracellular signaling mechanisms that specify tissue-specific responses to the
interleukin-6 (IL-6) family of cytokines are not well understood. Here, we evaluated the …

Although the cellular physiology of megakaryocyte and platelet production has been
understood for nearly a decade, the humoral basis of this process has remained enigmatic …

In recent years there has been a great deal of progress in understanding the homeostasis of
different tissue microenvironments, and this has been particularly true of the hematopoietic …

During early pregnancy, in response to the implanting embryo, the surrounding uterine
stroma undergoes a dramatic transformation into a specialized tissue known as the decidua …

Cytokines, currently known to be more than 130 in number, are small MW (< 30 kDa) key
signaling proteins that modulate cellular activities in immunity, infection, inflammation and …

Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …