Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

[HTML][HTML] Asia-Pacific consensus on long-term and sequential therapy for osteoporosis

TW Tai, HY Chen, CA Shih, CF Huang… - Osteoporosis and …, 2024 - Elsevier
Objectives This study aimed to present the Asia-Pacific consensus on long-term and
sequential therapy for osteoporosis, offering evidence-based recommendations for the …

Icariin inhibits osteoblast ferroptosis via Nrf2/HO-1 signaling and enhances healing of osteoporotic fractures

S Xiang, L Zhao, C Tang, L Ling, C Xie, Y Shi… - European Journal of …, 2024 - Elsevier
The incidence of osteoporotic fractures is increasing every year because of population aging
around the world. The reduced osteoblast activity in osteoporotic fracture has been …

Bone‐Targeting and Multishelled Oral Eldecalcitol Nanoparticles Improve Osteoporosis by Reconstruction of Osteogenic‐Osteoclastic Homeostasis

L Meng, W Ma, Y Jiang, X Li, M Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Current treatment of postmenopausal osteoporosis (PMOP) focuses on systemic
administration of medication, neglecting to proactively modulate the local microenvironment …

[HTML][HTML] Pip5k1c expression in osteocytes regulates bone remodeling in mice

S Lin, C Tao, Q Yan, H Gao, L Qin, Y Zhong… - Journal of Orthopaedic …, 2024 - Elsevier
Research background The role of osteocytes in maintaining bone mass has been
progressively emphasized. Pip5k1c is the most critical isoform among PIP5KIs, which can …

[HTML][HTML] Molecular mechanism of Achyranthis bidentatae radix and Morindae officinalis radix in osteoporosis therapy: An investigation based on network …

J Wang, Y Huang, L Guo, J Li, S Zhou - Biochemistry and Biophysics …, 2023 - Elsevier
Objective To investigate the targets and mechanism of Achyranthis bidentatae radix and
Morindae officinalis radix (ABR-MOR) for the treatment of osteoporosis (OP) by utilizing …

Enzyme-Activated Biomimetic Vesicles Confining Mineralization for Bone Maturation

J Chen, Q Zhao, J Tang, X Lei, J Zhang… - … Applied Materials & …, 2024 - ACS Publications
Inspired by the crucial role of matrix vesicles (MVs), a series of biomimetic vesicles (BVs)
fabricated by calcium glycerophosphate (CaGP) modified polyurethane were designed to …

Enhancing 3D DNA Walker-Induced CRISPR/Cas12a Technology for Highly Sensitive Detection of ExomicroRNA Associated with Osteoporosis

L Luo, F Dong, D Li, X Li, X Li, Y Fan, C Qi, J Luo… - ACS …, 2024 - ACS Publications
Exosomal microRNAs (exomiRNAs) have emerged as promising biomarkers for the early
clinical diagnosis of osteoporosis. However, their limited abundance and short length in …

[HTML][HTML] Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic and osteogenic niches in osteoporosis

G Zhang, Y Kang, J Dong, D Shi, Y Xiang, H Gao… - Bioactive Materials, 2024 - Elsevier
Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic
niches. Despite the development of nationally recognized first-line anti-osteoporosis drugs …

A Pyramid Deep Feature Extraction Model for the Automatic Classification of Upper Extremity Fractures

O Kaya, B Taşcı - Diagnostics, 2023 - mdpi.com
The musculoskeletal system plays a crucial role in our daily lives, and the accurate
diagnosis of musculoskeletal issues is essential for providing effective healthcare. However …