[HTML][HTML] An overview of the cardiorenal protective mechanisms of SGLT2 inhibitors

T Salvatore, R Galiero, A Caturano, L Rinaldi… - International Journal of …, 2022 - mdpi.com
Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

Glomerular hyperfiltration

M Cortinovis, N Perico, P Ruggenenti… - Nature reviews …, 2022 - nature.com
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Heart disease and stroke statistics—2017 update: a report from the American Heart Association

EJ Benjamin, MJ Blaha, SE Chiuve, M Cushman… - circulation, 2017 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Prevalence of obesity among adults and youth: United States, 2015–2016

CM Hales, MD Carroll, CD Fryar, CL Ogden - 2017 - stacks.cdc.gov
Obesity is associated with serious health risks (1). Monitoring obesity prevalence is relevant
for public health programs that focus on reducing or preventing obesity. Between 2003 …

Obesity and hypertension

G Seravalle, G Grassi - Obesity: Clinical, Surgical and Practical Guide, 2024 - Springer
Obesity is a worldwide pandemic contributing to the hypertensive state and to the
cardiovascular morbidity leading to an increase in hospitalizations, events and cost to the …

[HTML][HTML] High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction

Y Sun, X Ge, X Li, J He, X Wei, J Du, J Sun, X Li… - Cell death & …, 2020 - nature.com
Obesity has been recognized as a major risk factor for chronic kidney disease, but the
underlying mechanism remains elusive. Here, we investigated the mechanism whereby long …

Obesity and kidney disease: hidden consequences of the epidemic

CP Kovesdy, S Furth, C Zoccali… - Physiology …, 2017 - akjournals.com
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow
by 40% in the next decade. This increasing prevalence has implications for the risk of …

Differences in obesity prevalence by demographic characteristics and urbanization level among adults in the United States, 2013-2016

CM Hales, CD Fryar, MD Carroll, DS Freedman, Y Aoki… - Jama, 2018 - jamanetwork.com
Importance Differences in obesity by sex, age group, race and Hispanic origin among US
adults have been reported, but differences by urbanization level have been less studied …

Heart disease and stroke statistics—2016 update: a report from the American Heart Association

D Mozaffarian, EJ Benjamin, AS Go, DK Arnett… - circulation, 2016 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies

P Manna, SK Jain - Metabolic syndrome and related disorders, 2015 - liebertpub.com
Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …