Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

[HTML][HTML] The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing …

SP Wiertsema, J van Bergenhenegouwen, J Garssen… - Nutrients, 2021 - mdpi.com
Infectious diseases and infections remain a leading cause of death in low-income countries
and a major risk to vulnerable groups, such as infants and the elderly. The immune system …

Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Air pollution and central nervous system disease: a review of the impact of fine particulate matter on neurological disorders

H Kim, WH Kim, YY Kim, HY Park - Frontiers in public health, 2020 - frontiersin.org
Background: It is widely known that the harmful effects of fine dust can cause various
diseases. Research on the correlation between fine dust and health has been mainly …

Defining the scope of exposome studies and research needs from a multidisciplinary perspective

P Zhang, C Carlsten, R Chaleckis… - … science & technology …, 2021 - ACS Publications
The concept of the exposome was introduced over 15 years ago to reflect the important role
that the environment exerts on health and disease. While originally viewed as a call-to-arms …

The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis

S Lapehn, AG Paquette - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …

Heart healthy cities: genetics loads the gun but the environment pulls the trigger

T Münzel, M Sørensen, J Lelieveld… - European Heart …, 2021 - academic.oup.com
The world's population is estimated to reach 10 billion by 2050 and 75% of this population
will live in cities. Two-third of the European population already live in urban areas and this …

Spatiotemporal trends in human semen quality

J Auger, F Eustache, C Chevrier, B Jégou - Nature Reviews Urology, 2022 - nature.com
Over the past four decades, studies of various designs have reported spatial and temporal
trends in human semen quality. Several standardized-methodology studies in …

[HTML][HTML] Integrating the social environment with an equity perspective into the exposome paradigm: a new conceptual framework of the Social Exposome

H Gudi-Mindermann, M White, J Roczen, N Riedel… - Environmental …, 2023 - Elsevier
The importance of the social environment and social inequalities in disease etiology is well-
known due to the profound research and conceptual framework on social determinants of …