[HTML][HTML] Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
Signal peptide peptidase (SPP) and the homologous SPP-like (SPPL) proteases SPPL2a,
SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases …
SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases …
Alzheimer's disease due to loss of function: A new synthesis of the available data
KP Kepp - Progress in neurobiology, 2016 - Elsevier
Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …
cellular, and biochemical manifestations that are currently not understood in combination …
Three-dimensional structure of human γ-secretase
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a
membrane-embedded protease that controls a number of important cellular functions …
membrane-embedded protease that controls a number of important cellular functions …
Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
D Langosch, C Scharnagl, H Steiner… - Trends in biochemical …, 2015 - cell.com
Intramembrane proteolysis–cleavage of proteins within the plane of a membrane–is a
widespread phenomenon that can contribute to the functional activation of substrates and is …
widespread phenomenon that can contribute to the functional activation of substrates and is …
[HTML][HTML] Intracellular calcium dysregulation by the Alzheimer's disease-linked protein presenilin 2
Alzheimer's disease (AD) is the most common form of dementia. Even though most AD
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
cases are sporadic, a small percentage is familial due to autosomal dominant mutations in …
[HTML][HTML] Presenilins and γ-secretase in membrane proteostasis
N Oikawa, J Walter - Cells, 2019 - mdpi.com
The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease
(AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and …
(AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and …
Elucidating the protonation state of the γ-secretase catalytic dyad
DC Guzmán-Ocampo, R Aguayo-Ortiz… - ACS Chemical …, 2022 - ACS Publications
γ-Secretase (GS) is an intramembrane aspartyl protease that participates in the sequential
cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are …
cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are …
Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection
Highly penetrant autosomal dominant Alzheimer's disease (ADAD) comprises a distinct
disease entity as compared to the far more prevalent form of AD in which common variants …
disease entity as compared to the far more prevalent form of AD in which common variants …
Membrane dynamics of γ-secretase provides a molecular basis for β-amyloid binding and processing
AK Somavarapu, KP Kepp - ACS chemical neuroscience, 2017 - ACS Publications
γ-Secretase produces β-amyloid (Aβ) within its presenilin (PS1) subunit, mutations in which
cause Alzheimer's disease, and current therapies thus seek to modulate its activity. While …
cause Alzheimer's disease, and current therapies thus seek to modulate its activity. While …
[HTML][HTML] Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage
AA Papadopoulou, W Stelzer, M Silber, C Schlosser… - Scientific reports, 2022 - nature.com
Abstract Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl
protease that causes secretion of extracellular domains from type-II transmembrane …
protease that causes secretion of extracellular domains from type-II transmembrane …