Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Background Peripheral arterial disease (PAD) is estimated to affect 7% of the adult
population in the United States; however, there is currently little understanding of the key …

Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed
world with currently no effective pharmacological treatment available. CAVD results from a …

The clinical evidence has proven that valvular stenosis is closely related to many vascular
diseases, which attracts great academic attention to the corresponding pathological …

Practitioners have long recognized the involvement of inflammation in certain acute
cardiovascular diseases such as endocarditis, myocarditis, and pericarditis. Attention to the …

Myxomatous valve disease (MVD) can lead to cardiac dysfunction and heart failure, yet
medical therapies are lacking. CC chemokine receptor type 2 (CCR2)+ immune cell …

In situ heart valve tissue engineering approaches have been proposed as promising
strategies to overcome the limitations of current heart valve replacements. Tissue …

Method: Calcified aortic valve (CAV) samples from twenty patients (11 from Germany and 9
from Italy) with diagnosis of severe symptomatic CAVD were used to assess the presence of …

Type 2 diabetes mellitus (T2DM) undermines health and quality of life (QoL). This cross-
sectional study surveyed 138 consenting T2DM patients from North-Eastern Romania with …