Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies

W Liu, S Liu, P Li, K Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …

Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation

S Xu, M Momin, S Ahmed, A Hossain… - Advanced …, 2023 - Wiley Online Library
Optogenetic modulation of brain neural activity that combines optical and electrical modes in
a unitary neural system has recently gained robust momentum. Controlling illumination …

Photoacoustic carbon nanotubes embedded silk scaffolds for neural stimulation and regeneration

N Zheng, V Fitzpatrick, R Cheng, L Shi, DL Kaplan… - ACS …, 2022 - ACS Publications
Neural interfaces using biocompatible scaffolds provide crucial properties, such as cell
adhesion, structural support, and mass transport, for the functional repair of nerve injuries …

Frequency-specific optogenetic deep brain stimulation of subthalamic nucleus improves parkinsonian motor behaviors

C Yu, IR Cassar, J Sambangi… - Journal of Neuroscience, 2020 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for the
motor symptoms of Parkinson's disease (PD). However, the neural elements mediating …

Sonogenetic-based neuromodulation for the amelioration of Parkinson's disease

CH Fan, KC Wei, NH Chiu, EC Liao, HC Wang… - Nano …, 2021 - ACS Publications
Sonogenetics is a promising strategy allowing the noninvasive and selective activation of
targeted neurons in deep brain regions; nevertheless, its therapeutic outcome for …

Optogenetic activation of spinal microglia triggers chronic pain in mice

MH Yi, YU Liu, AD Umpierre, T Chen, Y Ying… - PLoS …, 2021 - journals.plos.org
Spinal microglia are highly responsive to peripheral nerve injury and are known to be a key
player in pain. However, there has not been direct evidence showing that selective …

Flexible fiber probe for efficient neural stimulation and detection

M Du, L Huang, J Zheng, Y Xi, Y Dai… - Advanced …, 2020 - Wiley Online Library
Functional probes are a leading contender for the recognition and manipulation of nervous
behavior and are characterized by substantial scientific and technological potential. Despite …

[PDF][PDF] Chemogenetic and optogenetic stimulation of zona incerta GABAergic neurons ameliorates motor impairment in Parkinson's disease

F Chen, J Qian, Z Cao, A Li, J Cui, L Shi, J Xie - Iscience, 2023 - cell.com
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in
the substantia nigra and leads to progressive motor dysfunction. While studies have focused …

[HTML][HTML] Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain

CY Wu, CH Fan, NH Chiu, YJ Ho, YC Lin, CK Yeh - Theranostics, 2020 - ncbi.nlm.nih.gov
Sonogenetics is a promising approach for in vivo neuromodulation using ultrasound (US) to
non-invasively stimulate cells in deep tissue. However, sonogenetics requires accurate …

Motor Neuron‐Specific Membrane Depolarization of Transected Peripheral Nerves by Upconversion Nanoparticle‐Mediated Optogenetics

J Yan, Y Wan, Z Ji, C Li, C Tao, Y Tang… - Advanced Functional …, 2023 - Wiley Online Library
It remains a fundamental challenge to administer guided regeneration and functional
recovery of peripheral nerves after the complete transection. Herein, a new concept to …