Fighting antibiotic resistance in hospital-acquired infections: current state and emerging technologies in disease prevention, diagnostics and therapy

E Avershina, V Shapovalova, G Shipulin - Frontiers in microbiology, 2021 - frontiersin.org
Rising antibiotic resistance is a global threat that is projected to cause more deaths than all
cancers combined by 2050. In this review, we set to summarize the current state of antibiotic …

Rapid methods for antimicrobial resistance diagnostics

GD Kaprou, I Bergšpica, EA Alexa, A Alvarez-Ordóñez… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is one of the most challenging threats in public health; thus,
there is a growing demand for methods and technologies that enable rapid antimicrobial …

PLSDB: advancing a comprehensive database of bacterial plasmids

GP Schmartz, A Hartung, P Hirsch, F Kern… - Nucleic Acids …, 2022 - academic.oup.com
Plasmids are known to contain genes encoding for virulence factors and antibiotic
resistance mechanisms. Their relevance in metagenomic data processing is steadily …

Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge

D Dai, C Brown, H Bürgmann, DGJ Larsson, I Nambi… - Microbiome, 2022 - Springer
Background There is concern that the microbially rich activated sludge environment of
wastewater treatment plants (WWTPs) may contribute to the dissemination of antibiotic …

Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks

I Mahdi, N Fahsi, M Hijri, M Sobeh - Frontiers in Microbiology, 2022 - frontiersin.org
Plant growth-promoting bacteria (PGPB) are endowed with several attributes that can be
beneficial for host plants. They opened myriad doors toward green technology approach to …

Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives

E Avershina, A Khezri, R Ahmad - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand
antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of …

SERS nanowire chip and machine learning-enabled classification of wild-type and antibiotic-resistant bacteria at species and strain levels

S Das, K Saxena, JC Tinguely, A Pal… - … Applied Materials & …, 2023 - ACS Publications
Antimicrobial resistance (AMR) is a major health threat worldwide and the culture-based
bacterial detection methods are slow. Surface-enhanced Raman spectroscopy (SERS) can …

BugSeq: a highly accurate cloud platform for long-read metagenomic analyses

J Fan, S Huang, SD Chorlton - BMC bioinformatics, 2021 - Springer
Background As the use of nanopore sequencing for metagenomic analysis increases, tools
capable of performing long-read taxonomic classification (ie. determining the composition of …

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

ST Girgis, E Adika, FE Nenyewodey… - Nature …, 2023 - nature.com
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …

Rapid detection of bacterial pathogens and antimicrobial resistance genes in clinical urine samples with urinary tract infection by metagenomic nanopore sequencing

L Zhang, W Huang, S Zhang, Q Li, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Urinary tract infections (UTIs) are among the most common acquired bacterial infections in
humans. The current gold standard method for identification of uropathogens in clinical …